Soper, R J and Oguz, C and Emery, R and Pitsillides, A A and Hodges, S J (2014) Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations. Molecular Nutrition & Food Research, 58 (8). pp. 1658-1666.
|
Text
8561.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial. Download (562kB) | Preview |
Abstract
The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐dependent bone proteins. We therefore tested the hypothesis that vitamin K catabolites, 5‐carbon (CAN5C) and 7‐carbon carboxylic acid (CAN7C) aliphatic side‐chain derivatives of the naphthoquinone moiety exert an osteotrophic role consistent with the treatment of osteoporosis.
| Item Type: | Article |
|---|---|
| RVC Publication Type: | Research (full) paper |
| WoS ID: | 000340528500008 |
| DOI: | https://doi.org/10.1002/mnfr.201400063 |
| Departments: | Comparative Biomedical Sciences |
| Research Programmes: | Comparative Physiology & Medicine > Musculoskeletal Biology |
| Depositing User: | RVC Auto-import |
| Last Modified: | 21 Nov 2020 07:23 |
| URI: | https://researchonline.rvc.ac.uk/id/eprint/8561 |
| Date Deposited: | 8 February 2019 |
Actions (Repository Editors)
 |
View Item |