Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations

Soper, R J and Oguz, C and Emery, R and Pitsillides, A A and Hodges, S J (2014) Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations. Molecular Nutrition & Food Research, 58 (8). pp. 1658-1666.

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Abstract

The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐dependent bone proteins. We therefore tested the hypothesis that vitamin K catabolites, 5‐carbon (CAN5C) and 7‐carbon carboxylic acid (CAN7C) aliphatic side‐chain derivatives of the naphthoquinone moiety exert an osteotrophic role consistent with the treatment of osteoporosis.

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