Betson, M and Sousa-Figueiredo, J C and Atuhaire, A and Arinaitwe, M and Adriko, M and Mwesigwa, G and Nabonge, J and Kabatereine, N B and Sutherland, C J and Stothard, J R (2014) Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment. Parasitology, 141 (14). pp. 1880-90.
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Abstract
During a longitudinal study investigating the dynamics of malaria in Ugandan lakeshore communities, a consistently high malaria prevalence was observed in young children despite regular treatment. To explore the short-term performance of artemether-lumefantrine (AL), a pilot investigation into parasite carriage after treatment(s) was conducted in Bukoba village. A total of 163 children (aged 2–7 years) with a positive blood film and rapid antigen test were treated with AL; only 8·7% of these had elevated axillary temperatures. On day 7 and then on day 17, 40 children (26·3%) and 33 (22·3%) were positive by microscopy, respectively. Real-time PCR analysis demonstrated that multi-species Plasmodium infections were common at baseline, with 41·1% of children positive for Plasmodium falciparum/Plasmodium malariae, 9·2% for P. falciparum/ Plasmodium ovale spp. and 8·0% for all three species. Moreover, on day 17, 39·9% of children infected with falciparum malaria at baseline were again positive for the same species, and 9·2% of those infected with P. malariae at baseline were positive for P. malariae. Here, chronic multi-species malaria infections persisted in children after AL treatment(s). Better point-of-care diagnostics for non-falciparum infections are needed, as well as further investigation of AL performance in asymptomatic individuals.
| Item Type: | Article |
|---|---|
| RVC Publication Type: | Research (full) paper |
| WoS ID: | 000346740700012 |
| DOI: | https://doi.org/10.1017/S003118201400033X |
| Departments: | Production and Population Health |
| Research Programmes: | Livestock Production and Health > Ecosystems Health |
| Depositing User: | RVC Auto-import |
| Last Modified: | 21 Nov 2020 07:37 |
| URI: | https://researchonline.rvc.ac.uk/id/eprint/8439 |
| Date Deposited: | 11 February 2019 |
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