Why has reversal of the actin-myosin cross-bridge cycle not been observed experimentally?

Loiselle, D S and Tran, K and Crampin, E J and Curtin, N A (2010) Why has reversal of the actin-myosin cross-bridge cycle not been observed experimentally? Journal of Applied Physiology, 108 (6). pp. 1465-71.

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