MicroCT optimisation for imaging fascicular anatomy in peripheral nerves

Thompson, N and Ravagli, E and Mastitskaya, S and Iacoviello, F and Aristovich, K and Perkins, J D M and Shearing, P R and Holder, D (2020) MicroCT optimisation for imaging fascicular anatomy in peripheral nerves. Journal of Neuroscience Methods. p. 108652. ISSN 01650270

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Abstract

Due to the lack of understanding of the fascicular organisation, vagus nerve stimulation (VNS) leads to unwanted off-target effects. Micro-computed tomography (microCT) can be used to trace fascicles from periphery and image fascicular anatomy. In this study, we present a simple and reproducible method for imaging fascicles in peripheral nerves with iodine staining and microCT for the determination of fascicular anatomy and organisation.

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