Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study

Noyce, A J and Kia, D A and Hemani, G and Nicolas, A and Price, T R and De Pablo-Fernandez, E and Haycock, P C and Lewis, P A and Foltynie, T and Smith, G D and Schrag, A and Lees, A J and Hardy, J and Singleton, A and Nalls, M A and Pearce, N and Lawlor, D A and Wood, N W (2017) Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLOS Medicine, 14 (6).

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Abstract

Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding or reverse causation. To our knowledge, Mendelian randomisation (MR)—the use of genetic instrumental variables (IVs) to explore causal effects—has not previously been used to test the effect of BMI on PD.

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