Network Analysis for Complex Neurodegenerative Diseases

Manzoni, C and Lewis, P A and Ferrari, R (2020) Network Analysis for Complex Neurodegenerative Diseases. Current Genetic Medicine Reports.

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Abstract

Biomedicine is witnessing a paradigm shift in the way complex disorders are investigated. In particular, the need for big data interpretation has led to the development of pipelines that require the cooperation of different fields of expertise, including medicine, functional biology, informatics, mathematics and systems biology. This review sits at the crossroad of different disciplines and surveys the recent developments in the use of graph theory (in the form of network analysis) to interpret large and different datasets in the context of complex neurodegenerative diseases. It aims at a professional audience with different backgrounds.