Aging and Mechanoadaptive Responsiveness of Bone

Javaheri, B and Pitsillides, A A (2019) Aging and Mechanoadaptive Responsiveness of Bone. Current Osteoporosis Reports, 17 (6). pp. 560-569.

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Abstract

Osteoporosis is an age-related disorder characterized by bone loss and increased fracture susceptibility. Whether this is due to reduced loading in less active elderly individuals or inherent modifications in bone cells is uncertain. We suppose that osteoporosis is nonetheless prima facie evidence for impaired mechanoadaptation; either capacity to accrue new bone declines, or the stimulus for such accrual is absent/can no longer be triggered in the aged. Herein, we provide only sufficient background to enable a focus on recent advances which seek to address such dilemmas.

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