Disturbed flow promotes endothelial senescence via a p53-dependent pathway

Warboys, C M and De Luca, A and Amini, N and Luong, L and Duckles, H and Hsiao, S and White, A and Biswas, S and Khamis, R and Chong, C K and Cheung, W M and Sherwin, S J and Bennett, M R and Gil, J and Mason, J C and Haskard, D O and Evans, P C (2014) Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34 (5). pp. 985-995.

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Abstract

Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately at branches and bends that are exposed to disturbed patterns of blood flow. The molecular mechanisms that link disturbed flow–generated mechanical forces with arterial injury are uncertain. To illuminate them, we investigated the effects of flow on endothelial cell (EC) senescence.

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