Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death

Galluzzi, L and Vitale, I and Aaronson, S A and Abrams, J M and Adam, D and Agostinis, P and Alnemri, E S and Altucci, L and Amelio, I and Andrews, D W and Annicchiarico-Petruzzelli, M and Antonov, A V and Arama, E and Baehrecke, E H and Barlev, N A and Bazan, N G and Bernassola, F and Bertran, M J M and Bianchi, K and Blagosklonny, M V and Blomgren, K and Borner, C and Boya, P and Brenner, C and Campanella, M and Others (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death. CELL DEATH AND DIFFERENTIATION, 25. pp. 486-541.

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Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

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