Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice

Javaheri, B and Razi, H and Piles, M and De Souza, R and Chang, Y M and Maric-Mur, I and Hopkinson, M and Lee, P D and Pitsillides, A A (2018) Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. OSTEOARTHRITIS AND CARTILAGE, 26 (6). pp. 807-817.

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Abstract

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explore whether early divergence in tibial bone mass or shape are linked to emergent OA.

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