Items where Author is "Lanyon, L E"

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Suswillo, R F L and Javaheri, B and Rawlinson, S C F and Dowthwaite, G P and Lanyon, L E and Pitsillides, A (2017) Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. CELL BIOCHEMISTRY AND FUNCTION, 35 (1). pp. 56-65.

Lanyon, L E (2016) Collecting the evidence for EBVM: who pays? VETERINARY RECORD, 178 (5). pp. 120-1.

Windahl, S H and Saxon, L K and Borjesson, A E and Lagerquist, M K and Frenkel, B and Henning, P and Lerner, U H and Galea, G L and Meakin, L B and Engdahl, C and Sjogren, K and Antal, M C and Krust, A and Chambon, P and Lanyon, L E and Price, J S and Ohlsson, C (2013) Estrogen Receptor-alpha Is Required for the Osteogenic Response to Mechanical Loading in a Ligand-Independent Manner Involving Its Activation Function 1 but Not 2. JOURNAL OF BONE AND MINERAL RESEARCH, 28 (2). pp. 291-301.

Delisser, P and Meakin, L and Galea, G L and Lanyon, L E and Suva, L and Price, J (2013) DISUSE SUFFICIENT TO CAUSE BONE LOSS INCREASES OSTEOCYTES' EXPRESSION OF SCLEROSTIN BUT HAS NO EFFECT ON OSTEOCYTE RANKL. JOURNAL OF BONE AND MINERAL RESEARCH, 28.

Galea, G L and Meakin, L B and Sugiyama, T and Zebda, N and Sunters, A and Taipaleenmaki, H and Stein, G S and van Wijnen, A J and Lanyon, L E and Price, J S (2013) Estrogen Receptor alpha Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost Is Mediated by Estrogen Receptor beta. JOURNAL OF BIOLOGICAL CHEMISTRY, 288 (13). pp. 9035-9048.

Sugiyama, T and Meakin, L B and Galea, G L and Lanyon, L E and Price, J S (2013) The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice. OSTEOPOROSIS INTERNATIONAL, 24 (1). pp. 383-388.

Saxon, L K and Galea, G L and Meakin, L B and Price, J S and Lanyon, L E (2012) Estrogen Receptors alpha and beta Have Different Gender-Dependent Effects on the Adaptive Responses to Load Bearing in Cancellous and Cortical Bone. Endocrinology, 153 (5). pp. 2254-2266.

Zaman, G and Sunters, A and Galea, G L and Javaheri, B and Saxon, L K and Moustafa, A and Armstrong, V J and Price, J S and Lanyon, L E (2012) Loading-related Regulation of Transcription Factor EGR2/Krox-20 in Bone Cells Is ERK1/2 Protein-mediated and Prostaglandin, Wnt Signaling Pathway-, and Insulin-like Growth Factor-I Axis-dependent. JOURNAL OF BIOLOGICAL CHEMISTRY, 287 (6). pp. 3946-3962.

Zaman, G and Sunters, A and Galea, G L and Javaheri, B and Saxon, L K and Moustafa, A and Armstrong, V J and Price, J S and Lanyon, L E (2012) Loading-related regulation of the transcription factor EGR2/Krox-20 in bone cells is ERK 1/2 mediated and prostaglandin Wnt and IGF-I axis dependent. JOURNAL OF BIOLOGICAL CHEMISTRY, 287 (6). pp. 3946-3962.

Javaheri, B and Sunters, A and Zaman, G and Suswillo, R F L and Saxon, L K and Lanyon, L E and Price, J S (2012) Lrp5 Is Not Required for the Proliferative Response of Osteoblasts to Strain but Regulates Proliferation and Apoptosis in a Cell Autonomous Manner. PLoS One, 7 (5). e35726.

Lanyon, L E (2012) A scientifically based profession? VETERINARY RECORD, 171 (5). pp. 128-129.

Saxon, L K and Jackson, B F and Sugiyama, T and Lanyon, L E and Price, J S (2011) Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it. BONE, 49 (2). pp. 184-193.

Moustafa, A and Sugiyama, T and Prasad, J and Zaman, G and Gross, TS and Lanyon, L E and Price, J S (2011) Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. OSTEOPOROSIS INTERNATIONAL, 23 (41). pp. 1225-1234.

Sugiyama, T and Meakin, L B and Galea, G L and Jackson, B F and Lanyon, L E and Ebetino, F H and Russell, R G G and Price, J S (2011) Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice. BONE, 49 (1). pp. 133-139.

Galea, G L and Sunters, A and Meakin, L B and Zaman, G and Sugiyama, T and Lanyon, L E and Price, J S (2011) Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4. FEBS LETTERS, 585 (15). pp. 2450-2454.

Sugiyama, T and Price, J S and Lanyon, L E (2010) Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. BONE, 46 (2). pp. 314-321.

Zaman, G and Saxon, L K and Sunters, A and Hilton, H and Underhill, P and Williams, D and Price, J S and Lanyon, L E (2010) Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse. BONE, 46 (3). pp. 628-642.

Sugiyama, T and Galea, G L and Lanyon, L E and Price, J S (2010) Mechanical Loading-Related Bone Gain Is Enhanced by Tamoxifen but Unaffected by Fulvestrant in Female Mice. Endocrinology, 151 (12). pp. 5582-5590.

Sunters, A and Armstrong, V J and Zaman, G and Kypta, R M and Kawano, Y and Lanyon, L E and Price, J S (2010) Mechano-transduction in Osteoblastic Cells involves Strain-regulated Estrogen Receptor -mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-. JOURNAL OF BIOLOGICAL CHEMISTRY, 285 (12). pp. 8743-8758.

Skerry, T M and Lanyon, L E (2009) Systemic and Contralateral Responses to Loading of Bones. JOURNAL OF BONE AND MINERAL RESEARCH, 24 (4). p. 753.

Moustafa, A and Sugiyama, T and Saxon, L K and Zaman, G and Sunters, A and Armstrong, V J and Javaheri, B and Lanyon, L E and Price, J S (2009) The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading. BONE, 44 (5). pp. 930-935.

Sugiyama, T and Saxon, L K and Zaman, G and Moustafa, A and Sunters, A and Price, J S and Lanyon, L E (2008) Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice. BONE, 43 (2). pp. 238-248.

Lanyon, L E (2008) Strain-related control of bone (re)modeling: objectives, mechanisms and failures. Journal of Musculoskeletal & Neuronal Interactions, 8 (4). pp. 298-300.

Armstrong, V J and Muzylak, M and Sunters, A and Zaman, G and Saxon, L K and Price, J S and Lanyon, L E (2007) Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. JOURNAL OF BIOLOGICAL CHEMISTRY, 282. pp. 20715-27.

Pead, M J and Skerry, T M and Lanyon, L E (2005) Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading. (Reprinted from J Bone Miner Res, vol 3, pg 647-656, 1988). JOURNAL OF BONE AND MINERAL RESEARCH, 20 (1). pp. 161-171.

De Souza, R L and Matsuura, M and Eckstein, F and Rawlinson, S C F and Lanyon, L E and Pitsillides, A A (2005) Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. BONE, 37 (6). pp. 810-818.

De Souza, R L and Pitsillides, A A and Lanyon, L E and Skerry, T M and Chenu, C (2005) Sympathetic nervous system does not mediate the load-induced cortical new bone formation. JOURNAL OF BONE AND MINERAL RESEARCH, 20 (12). pp. 2159-2168.

Lee, K C L and Lanyon, L E (2004) Mechanical loading influences bone mass through estrogen receptor alpha. EXERCISE AND SPORT SCIENCES REVIEWS, 32 (2). pp. 64-68.

Jessop, H L and Suswillo, R F L and Rawlinson, S C F and Zaman, G and Lee, K C L and Das-Gupta, V and Pitsillides, A A and Lanyon, L E (2004) Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. JOURNAL OF BONE AND MINERAL RESEARCH, 19 (6). pp. 938-946.

Lee, K C L and Jessop, H and Suswillo, R and Zaman, G and Lanyon, L E (2004) The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta. JOURNAL OF ENDOCRINOLOGY, 182 (2). pp. 193-201.

Noble, B S and Peet, N and Stevens, H Y and Brabbs, A and Mosley, J R and Reilly, G C and Reeve, J and Skerry, T M and Lanyon, L E (2003) Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 284 (4). C934-C943.

Mosley, J R and Lanyon, L E (2002) Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical strain. BONE, 30.

Cheng, M Z and Rawlinson, S C F and Pitsillides, A A and Zaman, G and Mohan, S and Baylink, D J and Lanyon, L E (2002) Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. JOURNAL OF BONE AND MINERAL RESEARCH, 17 (4). pp. 593-602.

Ehrlich, P J and Lanyon, L E (2002) Mechanical strain and bone cell function: A review. OSTEOPOROSIS INTERNATIONAL, 13 (9). pp. 688-700.

Jessop, H L and Rawlinson, S C F and Pitsillides, A A and Lanyon, L E (2002) Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. BONE, 31 (1). pp. 186-194.

Lee, K C L and Maxwell, A and Lanyon, L E (2002) Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. BONE, 31 (3). pp. 407-412.

Jessop, H L and Sjoberg, M and Cheng, M Z and Zaman, G and Wheeler-Jones, C P D and Lanyon, L E (2001) Mechanical strain and estrogen activate estrogen receptor alpha in bone cells. JOURNAL OF BONE AND MINERAL RESEARCH, 16 (6). pp. 1045-1055.

Lanyon, L E and Skerry, T M (2001) Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: A hypothesis. JOURNAL OF BONE AND MINERAL RESEARCH, 16 (11). pp. 1937-1947.

Lee, K C L and Maxwell, A and Lanyon, L E (2001) SUCCESSFUL ADAPTATION OF THE IN VIVO NON-INVASIVE ULNA LOADING TECHNIQUE FOR THE MOUSE. JOURNAL OF BONE AND MINERAL RESEARCH, 16. S362-S362.

Dodds, R A and Ali, N and Pead, M J and Lanyon, L E (1993) Early loading-related changes in the activity of glucose-6-phosphate-dehydrogenase and alkaline-phosphatase in osteocytes and periosteal osteoblasts in rat fibulae invivo. JOURNAL OF BONE AND MINERAL RESEARCH, 8 (3). pp. 261-267.

Dallas, S L and Zaman, G and Pead, M J and Lanyon, L E (1993) Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling invivo. JOURNAL OF BONE AND MINERAL RESEARCH, 8 (3). pp. 251-259.

Skerry, T M and Pead, M J and Lanyon, L E (1991) Modulation of bone loss during disuse by pulsed electromagnetic-fields. JOURNAL OF ORTHOPAEDIC RESEARCH, 9 (4). pp. 600-608.

Pead, M J and Lanyon, L E (1989) Indomethacin modulation of load-related stimulation of new bone-formation invivo. Calcified Tissue International, 45 (1). pp. 34-40.

Pead, M J and Skerry, T M and Lanyon, L E (1988) Direct transformation from quiescence to bone-formation in the adult periosteum following a single brief period of bone loading. JOURNAL OF BONE AND MINERAL RESEARCH, 3 (6). pp. 647-656.

Pead, M J and Suswillo, R and Skerry, T M and Vedi, S and Lanyon, L E (1988) Increased h-3 uridine levels in osteocytes following a single short-period of dynamic bone loading invivo. Calcified Tissue International, 43 (2). pp. 92-96.

Conference or Workshop Item

Windahl, S H and Saxon, L K and Borjesson, A E and Lagerquist, M K and Engdahl, C and Sjogren, K and Antal, M C and Krust, A and Chambon, P and Lanyon, L E and Price, J S and Ohlsson, C (2012) ESTROGEN RECEPTOR ALPHA AMPLIFIES THE OSTEOGENIC RESPONSE TO MECHANICAL LOADING IN A LIGAND-INDEPENDENT MANNER BY ITS ACTIVATION FUNCTION 1 BUT NOT 2. In: UNSPECIFIED.

Galea, G L and Sunters, A and Lanyon, L E and Price, J S (2011) SOST DOWN-REGULATION FOLLOWING MECHANICAL STRAIN IN HUMAN OSTEOBLASTIC CELLS IN VITRO INVOLVES THE PGE2/EP4 AND ERK SIGNALLING PATHWAYS. In: UNSPECIFIED.

Lanyon, L E and Price, J S (2009) ESTROGEN RECEPTOR ALPHA IS A CRITICAL CONTRIBUTOR AT MULTIPLE SITES TO BONES' ADAPTIVE RESPONSE TO MECHANICAL LOADING. In: UNSPECIFIED.

Sunters, A and Zaman, G and Armstrong, V J and Lanyon, L E and Price, J S (2008) AKT MEDIATED BETA-CATENIN ACTIVATION IN RESPONSE TO MECHANICAL STRAIN IN OSTEOBLASTS IS DEPENDENT ON IGF AND ESTROGEN RECEPTOR ALPHA BUT NOT PROSTAGLANDINS. In: UNSPECIFIED.

Moustafa, A M and Zaman, G and Saxon, L K and Lanyon, L E and Price, J S (2008) LOADING-RELATED REDUCTION IN OSTEOCYTE SCLEROSTIN EXPRESSION IN VIVO IS ASSOCIATED WITH BONE FORMATION IN TRABECULAR AND CORTICAL BONE. In: UNSPECIFIED.

Javaheri, B and Sunters, A and Zaman, G and Suswillo, R F L and Lanyon, L E and Price, J (2008) OSTEOBLAST-LIKE CELLS WITH THE LRP5 GAIN OF FUNCTION MUTATION SHOW GENDER-RELATED DIFFERENCES IN BASAL PROLIFERATION BUT NO ENHANCED RESPONSE TO MECHANICAL STRAIN. In: UNSPECIFIED.

Sunters, A and Muzya, M and Zaman, G and Armstrong, V J and Lanyon, L E and Price, J S (2007) AKT'S EFFECTS ON BETA-CATENIN REGULATE OSTEOBLASTS' RESPONSES TO NLECHANICAL STRAIN AND PTH. In: UNSPECIFIED.

Armstrong, V J and Muzylak, M and Sunters, A and Zaman, G and Saxon, L K and Price, J S and Lanyon, L E (2007) ESTROGEN RECEPTOR A IS REQUIRED FOR STRAIN-RELATED BETA-CATENIN SIGNALING IN OSTEOBLASTS. In: UNSPECIFIED.

Armstrong, V J and Muzylak, M and Sunters, A and Zaman, G and Saxon, L K and Price, J S and Lanyon, L E (2007) ESTROGEN RECEPTOR ALPHA IS REQUIRED FOR STRAIN-RELATED BETA-CATENIN SIGNALING IN OSTEOBLASTS. In: UNSPECIFIED.

Saxon, L K and Sugiyama, T and Price, J S and Lanyon, L E (2007) THE LRP5 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH AN INCREASED OSTEOGENIC RESPONSE TO LOADING IN TRABECULAR AS WELL AS CORTICAL BONE IN FEMALE BUT NOT MALE MICE. In: UNSPECIFIED.

Zaman, G and Saxon, L K and Muzylak, M and Price, J S and Lanyon, L E (2007) MECHANICAL LOADING INDUCED WNT/BETA-CATENIN SIGNALING IS COMPROMISED IN ER ALPHA-/- MOUSE TIBIA - IN VIVO MICROARRAY ANALYSIS. In: UNSPECIFIED.

Moun, J G and Allen, S P and Muzylak, M and Lanyon, L E and Goodship, A E and McGonnell, I M and Price, J S (2007) OSTEOBLASTS IN ADULT BONE USE SLUG FOR REGENERATION AND REPAIR BUT NOT REMODELLING. In: UNSPECIFIED.

Ehrlich, P J and Noble, B S and Jessop, H L and Stevens, H Y and Mosley, J R and Lanyon, L E (2002) The effect of in vivo mechanical loading on estrogen receptor alpha expression in rat ulnar osteocytes. In: UNSPECIFIED.

Other

Sugiyama, T and Saxon, L K and Zaman, G and Moustafa, A and Sunters, A and Price, J S and Lanyon, L E (2009) ERRATUM TO MECHANICAL LOADING ENHANCES THE ANABOLIC EFFECTS OF INTERMITTENT PARATHYROID HORMONE (1-34) ON TRABECULAR AND CORTICAL BONE IN MICE. UNSPECIFIED.

This list was generated on Sun Nov 17 07:12:02 2019 GMT.