Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
(2025)
Journal Article
Dreyer, T., Keen, J., Wells, L., Hopkinson, M., Orriss, I., Holdsworth, G., Pitsillides, A., & Roberts, S. (2025). Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies. Bone Research, 13(1), https://doi.org/10.1038/s41413-025-00406-3
Sclerosteosis, an ultra-rare disorder characterised by high bone mass (HBM) and skeletal overgrowth, leads to facial paralysis, hearing loss and raised intracranial pressure, which is currently managed only through high-risk surgery. Sclerosteosis is...
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