Theileria Apicoplast as a Target for Chemotherapy

Lizundia, R and Werling, D and Langsley, G and Ralph, S A (2009) Theileria Apicoplast as a Target for Chemotherapy. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 53 (3). pp. 1213-1217.

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Abstract

Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.