Pruritus is a common feature in sheep infected with the BSE agent

Konold, T and Bone, G and Vidal-Diez, A and Tortosa, R and Davis, A and Dexter, G and Hill, P and Jeffrey, M and Simmons, M M and Chaplin, M J and Bellworthy, S J and Berthelin-Baker, C (2008) Pruritus is a common feature in sheep infected with the BSE agent. BMC Veterinary Research, 4. p. 16.

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Abstract

Background: The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, breed, clinical duration, dose, route and type of inoculum and the age at infection. The study aimed to describe the clinical signs in sheep infected with the BSE agent throughout its clinical course to determine whether the clinical signs were as variable as described for classical scrapie in sheep. The clinical signs were compared to BSE-negative sheep to assess if disease-specific clinical markers exist.