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Welcome to RVC Repository

RVC Research Online is a repository of the research outputs produced by staff from the Royal Veterinary College (RVC). The aims of the repository are (i) to provide an institutional archive of RVC's research outputs, (ii) to provide access to these outputs and support open science, and (iii) to increase the reach and impact of RVC's research.

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Latest Additions

Evaluation of Decreased Kidney Function in Dogs Receiving Carboplatin: A Retrospective Cohort Study of 98 Dogs (2006–2024) (2025)
Journal Article
Yale, A., So, A., Guillen, A., Desmas-Bazelle, I., Rogato, F., & Jepson, R. (2025). Evaluation of Decreased Kidney Function in Dogs Receiving Carboplatin: A Retrospective Cohort Study of 98 Dogs (2006–2024). Veterinary and Comparative Oncology, https://doi.org/10.1111/vco.13069

Decreased kidney function is observed in some people receiving carboplatin, but limited literature explores this in dogs. The aim of this study was to evaluate the incidence and risk factors for decreased kidney function in dogs receiving carboplatin... Read More about Evaluation of Decreased Kidney Function in Dogs Receiving Carboplatin: A Retrospective Cohort Study of 98 Dogs (2006–2024).

Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells (2025)
Journal Article
Wallace, M. D., Herrtage, M. E., Gostelow, R., Owen, L., Rutherford, L., Hughes, K., Denyer, A., Catchpole, B., O’Callaghan, C. A., & Davison, L. J. (2025). Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells. Veterinary Oncology, 2(1), https://doi.org/10.1186/s44356-025-00026-3

Single-cell transcriptome conservation in a multispecies comparative analysis of fresh and cryopreserved insulinoma cell lines (2025)
Journal Article
Buishand, F. O., Chan, P. Y. K., Xia, D., & Davison, L. J. (2025). Single-cell transcriptome conservation in a multispecies comparative analysis of fresh and cryopreserved insulinoma cell lines. Veterinary Oncology, 2(1), https://doi.org/10.1186/s44356-025-00025-4

Background Insulinoma is the most common pancreatic neuroendocrine tumour in dogs and humans. The understanding of driving factors and critical survival genes in insulinomas is limited and overall survival is poor for canine and human malignant insul... Read More about Single-cell transcriptome conservation in a multispecies comparative analysis of fresh and cryopreserved insulinoma cell lines.

Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds (2025)
Journal Article
Meunier, D., Corona-Torres, R., Boulton, K., Wu, Z., Ballantyne, M., Glendinning, L., Ahmad, A. A., Borowska, D., Taylor, L., Vervelde, L., del Pozo, J., Vasilogianni, M., Jaramillo-Ortiz, J., Sanchez-Arsuaga, G., Psifidi, A., Tomley, F., Watson, K. A., McGrew, M. J., Stevens, M. P., Blake, D. P., & Hume, D. A. (2025). Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds. eLife, https://doi.org/10.7554/elife.106252.1

Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory cytokine IL10 regulates these processes in the in... Read More about Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds.