E-cadherin expression in canine cutaneous histiocytomas

Baines, S J and McInnes, E F and McConnell, I (2008) E-cadherin expression in canine cutaneous histiocytomas. VETERINARY RECORD, 162 (16). pp. 509-513.

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Abstract

Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. in all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.