Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide

Wilson, R and Bate, C and Boshuizen, R and Williams, A and Brewer, J (2007) Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. Bmc Neuroscience, 8.

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Abstract

Background: Neurotoxic peptides derived from the protease-resistant core of the prion protein are used to model the pathogenesis of prion diseases. The current study characterised the ingestion, internalization and intracellular trafficking of a neurotoxic peptide containing amino acids 105-132 of the murine prion protein (MoPrP105-132) in neuroblastoma cells and primary cortical neurons.