Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Staines, K A and Ikpegbu, E and Tornqvist, A E and Dillon, S and Javaheri, B and Amin, A K and Clements, D N and Buttle, D J and Pitsillides, A A and Farquharson, C (2019) Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC MUSCULOSKELETAL DISORDERS, 20.

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Abstract

Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB osteocyte network contributes to the initiation and pathogenesis of osteoarthritis.