Zebrafish as a model for kidney function and disease

Outtandy, P and Russell, C and Kleta, R and Brockenhauer, D (2019) Zebrafish as a model for kidney function and disease. Pediatric Nephrology, 34 (5). pp. 751-762.

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Abstract

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease.