Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis

Berk, B A and Hering, K and Kortmann, R-D and Hoffmann, K-T and Ziemer, M and Seidel, C (2019) Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma - results from a retrospective comparative analysis. Clinical Neurology and Neurosurgery. (In Press)

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Abstract

Brain metastasis (BM) is a major complication of different cancers. There is increasing evidence for influence of vascular factors on BM in patients with non-small cell lung cancer (NSCLC). It is not known if the same is true for other tumors that might rely on different forms of vasculogenesis. The objective of this retrospective study was to evaluate a possible negative association of vascular white matter lesions and vascular risk factors (vasRF) with brain metastases in patients with melanoma.