LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION

Gilroy, D W and Bishop-Bailey, D (2019) LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION. BRITISH JOURNAL OF PHARMACOLOGY, 176 (8).

[img] Text
11916.pdf - Accepted Version
Restricted to Repository staff only until 25 January 2020.
Available under License Creative Commons Attribution Non-commercial.

Download (1MB)

Abstract

We are all too familiar with the events that follow a bee sting – heat, redness, swelling and pain. These are Celsus’ four cardinal signs of inflammation that are driven by very well defined signals and hormones; in fact targeting the factors that drive this onset phase is the basis upon which most current anti‐inflammatory therapies were developed. We are also very well aware that within a few hours these cardinal signs normally disappear. In other words, inflammation resolves. When it does not, inflammation persists resulting in damaging chronic conditions. While inflammatory onset is actively driven so also is its resolution – years of research has identified novel internal counter‐regulatory signals that work together to switch off inflammation. Among these signals, lipids are potent signaling molecules that regulate an array of immune responses including vascular hyper reactivity and pain as well as leukocyte trafficking and clearance, so‐called resolution. Here, we collate bioactive lipid research to date and summarise the major pathways involved in their biosynthesis and their role in inflammation as well as resolution.