Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation

Martinez, M and Gehring, R and Mochel, J P and Pade, D and Pelligand, L (2018) Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41 (4). E-68.

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Abstract

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of population variability. Part II provides a summary of discussions on modelling and simulation tools that utilize existing pharmacokinetic data, can integrate drug physicochemical characteristics with species physiological characteristics and dosing information or that combine observed with predicted and in vitro information to explore and describe sources of variability that may influence the safe and effective use of veterinary pharmaceuticals.