Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

Deas, E and Cremades, N and Angelova, P R and Ludtmann, M H R and Yao, Z and Chen, S and Horrocks, M H and Banushi, B and Little, D and Devine, M J and Gissen, P and Klenerman, D and Dobson, C M and Wood, N W and Gandhi, S and Abramov, A Y (2016) Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. Antioxidants & Redox Signaling, 24 (7). pp. 376-91.

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Abstract

Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its monomeric form to its soluble oligomeric state results in aberrant free radical production and neuronal toxicity.