Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans

Hu, X and Charles, J P and Akay, T and Hutchinson, J R and Blemker, S S (2017) Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans. Skeletal Muscle, 7 (26).

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Abstract

The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently fail to translate to humans due to various factors. Differences in muscle function between the two species could be crucial but often have been overlooked. The purpose of this study was to evaluate and compare muscle excursions in walking between mice and humans.