A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus

Ali, A and Wathes, D C and Swali, A and Burns, H and Burns, S (2017) A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus. Biochemistry and Biophysics Reports, 12. pp. 151-157.

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Abstract

We report the discovery of a polyphosphate-dependent enzyme system in mammalian cells with kinetics similar to established ATP-dependent glucokinase, also known to have a nuclear location. The kinetics suggest possible regulatory or redox protective roles.