RVC Research Online

Evaluation of use of human albumin in critically ill dogs: 73 cases (2003-2006)

Trow, A V and Rozanski, E A and Delaforcade, A M and Chan, D L (2008) Evaluation of use of human albumin in critically ill dogs: 73 cases (2003-2006). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 233 (4). pp. 607-612.

[img] Text
1714.pdf
Restricted to Repository staff only

Download (394kB)

Abstract

Objectives-To evaluate the use of human albumin in critically ill dogs. Design-Retrospective case series. Animals-73 client-owned hospitalized dogs. Procedures-Medical records of dogs that received human albumin were reviewed to assess effects of the use of human albumin on serum albumin concentration, colloid osmotic pressure, and total protein concentration; determine the relationships between these variables and outcome; and assess its safety. Data for signalment, diagnoses, physiologic variables, dosage, amount of crystalloid fluid administered prior to human albumin administration, complications, and outcome were reviewed. Additionally, pre- and postadministration values for serum albumin, colloid osmotic pressure, and total protein were recorded. Results-Administration of human albumin resulted in significant changes in serum albumin, colloid osmotic pressure, and total protein. The serum albumin, total protein, degree of improvement in serum albumin, colloid osmotic pressure, and dosage of human albumin were significantly greater in survivors. Seventeen of 73 (23%) dogs had at least I complication that could be potentially associated with the administration of human albumin that occurred during or immediately following administration of human albumin. Three of 73 (4%) dogs had severe delayed complications. Conclusions and Clinical Relevance-Administration of human albumin significantly increased serum albumin, and total protein concentrations and colloid osmotic pressure, especially in survivors. Because of the high mortality rate of the study population and other confounding factors, it was uncertain whether complications were associated with the underlying disease or with human albumin administration. Acute and delayed complications may have been under-recognized.

Item Type: Article
RVC Publication Type: Research (full) paper
WoS ID: 000258507700022
Departments: Clinical Sciences and Services
Research Programmes: Comparative Physiology & Medicine > Clinical Research
Depositing User: RVC Auto-import
Date Deposited: 11 Nov 2014 18:42
Last Modified: 30 Aug 2016 05:03
URI: http://researchonline.rvc.ac.uk/id/eprint/1714