RVC Research Online

Equine recurrent airway obstruction and insect bite hypersensitivity: Understanding the diseases and uncovering possible new therapeutic approaches

Cunningham, F M and Dunkel, B (2008) Equine recurrent airway obstruction and insect bite hypersensitivity: Understanding the diseases and uncovering possible new therapeutic approaches. VETERINARY JOURNAL, 177 (3). pp. 334-344.

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Abstract

Recurrent airway obstruction (RAO) and insect bite hypersensitivity (IBH) are allergic conditions that are commonly encountered in the horse. Whilst complete allergen avoidance is an effective management strategy for both diseases, this may not be achievable in all cases and treatment options are therefore required. The inflammatory response is the main therapeutic target for glucocorticoids given to horses with RAO and severe cases of IBH, whilst the bronchodilators used in RAO primarily target airway smooth muscle. Such drugs are effective in most but not all individuals and there may be unwanted adverse effects. This article will review how knowledge of drug action and the pathogenesis of RAO and IBH can be utilised to identify potential targets for novel therapeutic agents that, in the longer term, may be safer and/or more effective in managing the allergic horse. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type: Article
Article Type: Review
RVC Publication Type: Review
WoS ID: 000258041300007
DOI: https://doi.org/10.1016/j.tvjl.2007.10.005
Departments: Clinical Sciences and Services
Comparative Biomedical Sciences
Depositing User: RVC Auto-import
Date Deposited: 11 Nov 2014 18:45
Last Modified: 25 Aug 2016 05:01
URI: http://researchonline.rvc.ac.uk/id/eprint/1411