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Welcome to RVC Repository

RVC Research Online is a repository of the research outputs produced by staff from the Royal Veterinary College (RVC). The aims of the repository are (i) to provide an institutional archive of RVC's research outputs, (ii) to provide access to these outputs and support open science, and (iii) to increase the reach and impact of RVC's research.

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Latest Additions

Insulin expression in beta cells is reduced within islets before islet loss in diabetic cats (2022)
Journal Article
Bergomi, V., Beck, S., Dobromylskya, M., Davison, L., Wills, J., & Hughes, K. (in press). Insulin expression in beta cells is reduced within islets before islet loss in diabetic cats. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13541

Objectives Diabetes mellitus is a common condition that requires intensive treatment and markedly impacts the welfare of affected cats. The aim of this study was to identify diabetes mellitus-associated perturbations in the feline pancreatic islet mi... Read More about Insulin expression in beta cells is reduced within islets before islet loss in diabetic cats.

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease (2024)
Journal Article
Jiang, J., Hiron, T. K., Agbaedeng, T., Malhotra, Y., Drydale, E., Bancroft, J., …O’Callaghan, C. A. (in press). A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Circulation Research, https://doi.org/10.1161/circresaha.123.324172

BACKGROUND: Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 genetic risk loci have been identified through genome-wide association studies, the specifi... Read More about A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.

Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target? (2024)
Journal Article
Ritson, M., Wheeler-Jones, C. P., & Stolp, H. B. (2024). Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?. Journal of Neuroimmunology, 391, 578363. https://doi.org/10.1016/j.jneuroim.2024.578363

Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level... Read More about Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?.